名称：抗TRIM63抗体(anti- TRIM63 antibody)

　　货号：FNab08992

　　适应种属：人源，大鼠，小鼠

　　规格：100ug(微克)

　　状态：液体

　　纯化方法：免疫亲和纯化

　　纯度：经sds-page分析,纯度大于95

　　宿主：兔

　　亚型：igg

　　存储：用添加了0.02叠氮化钠和50甘油的pbs溶解,ph值7.3,可在-20℃下保存12个月（避免反复冻融）

　　免疫原：tripartite motif-containing 63

　　免疫原别称：FLJ32380, IRF, Iris RING finger protein, MuRF 1, MURF1, MURF2, RING finger protein 28, RNF28, SMRZ, TRIM63, tripartite motif containing 63

　　分子量：40 kDa

　　验证应用：ELISA, WB, IHC, IF

　　建议稀释比例：WB: 1:200-1:1000; IHC: 1:20-1:200; IF: 1:10-1:100

　　克隆性：多克隆

　　uniprot id：Q969Q1

　　背景介绍：E3 ubiquitin ligase. Mediates the ubiquitination and subsequent proteasomal degradation of CKM, GMEB1 and HIBADH. Regulates the proteasomal degradation of muscle proteins under amino acid starvation, where muscle protein is catabolized to provide other organs with amino acids. Inhibits de novo skeletal muscle protein synthesis under amino acid starvation. Regulates proteasomal degradation of cardiac troponin I/TNNI3 and probably of other sarcomeric-associated proteins. May play a role in striated muscle atrophy and hypertrophy by regulating an anti-hypertrophic PKC-mediated signaling pathway. May regulate the organization of myofibrils through TTN in muscle cells。

　　图像：

　　Immunohistochemistry of paraffin-embedded human heart using FNab08992(TRIM63 antibody) at dilution of 1:50。

　　Immunofluorescent analysis of HeLa cells using FNab08992 (TRIM63 antibody) at dilution of 1:25 and Rhodamine-Goat anti-Rabbit IgG。

　　mouse heart tissue were subjected to SDS PAGE followed by western blot with FNab08992(TRIM63 antibody) at dilution of 1:300。